Rx Safety Information - Tangl BROW

You must always read this safety information before starting this medication and with every refill. There may be new information. This information is not a substitute for discussing your medical condition or treatment with your healthcare provider.

This compounded product has not been approved by the FDA. It is only available if prescribed by a dermatologist  through Tangl who will determine if treatment is suitable. 

What I need to know about Tangl BROW: 

  • Tangl BROW is a compounded topical medication combining Latanoprost, topical minoxidil, caffeine and melatonin.
  • Latanoprost is a medication primarily used for the treatment of glaucoma, an eye condition that causes increased pressure within the eye. There have been some studies and discussions about the potential use of latanoprost for promoting hair growth. The idea emerged from observations that some patients using latanoprost for glaucoma treatment experienced increased eyelash growth as a side effect. This led to its off-label use in treating conditions like alopecia (hair loss).  
  • Topical minoxidil is a widely used medication for the treatment of hair loss, including androgenetic alopecia. 
  • Caffeine and melatonin are compounded together to be used off-label as a supportive topical therapy aiding in better absorption of the ingredients, an optimized scalp environment, and improving the hair growth cycle.

Absolute Contraindications – DO NOT use Tangl BROW if you: 

  • Are allergic to any of the active ingredients
  • Are under 18 or are pregnant, breastfeeding, or planning to become pregnant
  • Have eye pressure problems, history of intraocular inflammation (uveitis/iritis)
  • Have been diagnosed with glaucoma
  • Have risk factors for macular edema
  • Have been diagnosed with aphakia (no lens in eye) pseudophakia (artificial eye, or a torn posterior lens capsule
  • Have any present or past cancer, heart failure, kidney problems or liver problems (see a doctor in-person about seeking treatment with Tangl BROW) 


Drug Interactions – DO NOT use Tangl BROW if you take: 

  • Certain blood pressure medications (see a doctor in person about seeking treatment with Tangl BROW)  

Serious Side Effects – STOP treatment and seek emergency medical care or call 911 if you experience:  

  • Hypotension (low blood pressure) or worsening of renal (kidney) function
  • Fluid retention or swelling in the face, hands, legs, feet or elsewhere
  • Feeling faint, shortness of breath, chest pain, or difficulty breathing 
  • Severe skin irritation

 

It’s important to closely and regularly monitor for these side effects while taking Tangl BROW, especially when starting or changing your dose, as they can indicate a severe reaction. If you notice any side effects, stop using Tangl BROW and seek immediate medical attention, or call 911. 

Common Side Effects  – Talk to your provider about changing your dose/treatment if you experience: 

  • Headache   
  • Eyebrow irritation, including redness, itching or minor swelling
  • Latanoprost has been reported to cause changes to pigmented tissues. The most frequently reported changes have been increased pigmentation of the iris, periorbital tissue (eyelid), and eyelashes. Pigmentation around the skin is expected to increase as long as latanoprost is applied.
  • Eyebrow hair shedding: It's common to experience increased hair shedding initially. This is typically a temporary phase as hair follicles regenerate. 
  • Unwanted hair growth on the face or body
  • Some may also experience changes in hair texture and color. 


These are not all the possible side effects of Tangl BROW. For more information, ask your healthcare provider or pharmacist and refer to the complete prescribing information: Latanoprost, Topical Minoxidil, Caffeine, Melatonin

WARNING: POSSIBLE CARDIAC RISK
In rare cases topical minoxidil, one of the active ingredients in Tangl BROW can lead to cardiovascular side effects. Pericardial effusions, which is the excessive buildup of fluid in the sac surrounding the heart (pericardium), have been reported in patients taking minoxidil. This can progress to cardiac tamponade, which is a life-threatening condition where the fluid pressure compresses the heart, preventing it from effectively pumping blood. Symptoms encompass sharp chest pain and breathing difficulties. If you notice these symptoms, stop treatment and seek immediate emergency medical care. 

Always use Tangl BROW under the supervision of a healthcare professional and undergo regular medical assessments during treatment.

WARNING: TOXIC TO PETS  

  • Minoxidil, one of the active ingredients in Tangl BROW is highly toxic to animals, especially cats; even trace amounts can be life-threatening. 
  • Do not apply minoxidil if pets are in close proximity
  • Do not approach your pets until the treated area has thoroughly dried
  • Wash hands and surfaces thoroughly after application
  • Do not let pets near the application site (i.e. do not hold pets near your face/hair)
  • Beware of pillowcases: minoxidil can transfer to pillowcases during sleep. To prevent any risk to your pets, especially cats, consider removing or replacing pillowcases after use. Alternatively, ensure that your pets do not have access to areas where pillows might be.
  • Always store Tangl BROW in a secure location out of reach of pets. 
  • If you suspect your pet has come into contact with minoxidil or displays symptoms such as lethargy, rapid breathing, vomiting, or collapse, seek emergency veterinary care immediately.

Always Inform Medical Professionals: Always consult a healthcare provider immediately about any unusual side effects, concerns or changes noticed during treatment. You can message your Tangl dermatologist through your Tangl account (trytangl.com/account) if you have any questions or concerns about your treatment. 

Always Provide Accurate Health Information: Failing to provide accurate information about your health and medical history can lead to severe consequences, including harm or, in some instances, death.

Report Side Effects to the FDA: Negative side effects should be reported to the FDA at www.fda.gov/medwatch  or call 1-800-FDA-1088.

Instructions For Use:

  • Follow your healthcare provider's specific instructions when using this medication
  • Do not apply this medication more than the recommended dose; doing so won't enhance results and may raise the likelihood of side effects
  • Wash your hands with soap after application
  • This product is meant solely for your eyebrows, repeated contact with other skin areas can potentially result in unwanted hair growth. If the medication accidentally gets on your face, wash it off with soap and water immediately.
  • Do not apply on other parts of the body
  • Avoid contact with the eyes. In case of accidental contact, rinse eyes with copious amounts of cool tap water 
  • Do not use this medication for a condition for which it was not prescribed.
  • Never share this medication with others, even if their symptoms are similar to yours. It may be harmful to them. 

Storage Information

  • Keep this medication at a room temperature 
  • Dispose of the medication if you are no longer using it. 
  • Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Disclaimer: The FDA has not evaluated all the claims made here. This medication is not guaranteed to diagnose, treat, cure, or prevent any disease. Individual results may vary.This information is not comprehensive. Please see the full prescribing link below for complete safety information: Latanoprost, Topical Minoxidil, Caffeine, Melatonin