• Our most powerful hair regrowth formula. Combines five science backed ingredients into a convenient, easy to use application.
• Emerging research shows topical application may reduce the risk of side effects.
• Doctor formulated, made specifically for women.
• Available in a scalp roll-on or dropper bottle.
• Non-irritating, scalp-friendly formula that does not contain propylene glycol (a common irritant in hair loss treatments).

Contains minoxidil, an ingredient clinically shown to regrow hair in 3-6 months.*

Spironolactone (0.5%): An FDA-approved oral medication initially intended for managing fluid retention and high blood pressure, now finds new purpose off-label in the fight against hair loss. Its key strength lies in its ability to block androgens, including DHT (dihydrotestosterone), a hormone responsible for hair loss. These actions directly influence the health of hair follicles, making it a potent tool for combatting hair loss, especially in women.

Minoxidil (5%): Topical minoxidil is an FDA-approved hair loss treatment. It directly stimulates hair growth at the follicle, promoting vasodilation and extending the hair growth phase, leading to thicker, healthier hair.

Cetirizine racemate (1%): Cetirizine blocks the release of prostaglandin D2 and stimulates the release of prostaglandin E2. These prostaglandins play a vital role in regulating the hair growth cycle, contributing to healthier and more robust hair.

Caffeine (0.2%): Topical caffeine is used in hair loss treatments because it can stimulate hair follicles and promote hair growth. It works by increasing blood circulation to the scalp, which ensures that hair follicles receive more nutrients and oxygen, supporting their overall health. Caffeine can also help extend the anagen (growth) phase of the hair cycle and may counteract the effects of dihydrotestosterone (DHT), a hormone associated with hair loss.

Melatonin (0.1%): Topical melatonin is used in hair loss treatments due to its antioxidant and its ability to soothe and calm the scalp, which can protect hair follicles from damage, reduce irritation in the scalp, and stimulate hair follicles. It may also enhance blood circulation to the scalp and potentially extend the growth phase of hair.

Roller: Roll across the affected area of the scalp 5 times (equivalent to 1ml), once daily.

Dropper: Apply 1 ml of solution to affected areas of the scalp, once daily.

*Exact dosages will be determined by your Tangl dermatology provider.

Spiroxidil™ is best suited for women who are premenopause, experiencing hair loss, thinning, shedding, or weakening of existing hair.

It may be helpful for conditions like:

• AGA (Androgenetic Alopecia)
• PCOS-related hair loss
• Birth control-related hair loss
• Postpartum hair loss
• Thyroid hair loss
• Hair loss due to hormonal imbalances
• Telogen effluvium (temporary, diffuse hair shedding triggered by stress, illness, surgery, or other transient factors)
• Anemia-related hair loss
• Traction alopecia (from tight hairstyles)
• Hair loss from nutritional deficiencies (e.g., vitamin D, biotin)

Do not use if you are pregnant, breastfeeding, or planning to become pregnant in the near future.

Tangl treatments are not appropriate for some types of hair loss, including inflammatory/scarring types of hair loss (scarring, or cicatricial alopecia). If you have active symptoms of inflammation on your scalp (pain, redness, severe itching, active rash, sores, pus bumps) it is advised that you get in person evaluation and treatment to control these symptoms prior to starting hair loss therapy.

No, you should not use topical Spiroxidil™ if you are pregnant, breastfeeding, or planning to become pregnant.

Spiroxidil™ is a compounded medication prescribed for topical use in women with androgenetic alopecia and other forms of hair loss. As a compound, it blends multiple active ingredients to create a tailored treatment to target and address different aspects of hair loss.

The main ingredients in Spiroxidil™ are Spironolactone and Minoxidil. Spironolactone is an anti-androgen that blocks the effects of male hormones, specifically DHT, on the scalp. DHT is known to contribute to hair thinning and loss by shrinking hair follicles and shortening the growth phase. By inhibiting androgen activity directly on the scalp, Spironolactone helps to preserve existing hair and, in some cases, stimulates the growth of new, thicker hair.

Minoxidil is an FDA-approved hair loss treatment that stimulates hair growth by promoting blood flow and extending the hair growth phase. Together, these ingredients create a powerful combination for treating AGA and female hair loss, leading to the preservation of existing hair and the stimulation of new, thicker hair growth.

Spiroxidil™ is also enriched with Cetirizine racemate to regulate the hair growth cycle, Caffeine to stimulate follicles and improve scalp circulation, and Melatonin for its antioxidant properties and scalp-soothing effects. This comprehensive blend of ingredients makes Spiroxidil™ a powerful treatment for various types of hair loss in women.

Hair growth is a slow process and it can take several months to see substantial results. It can take 3 to 6 months to evaluate the effects of your topical Spiroxidil™ treatment, but for some patients the full effect may only be visible after 7-12 months. It is important to stay on the medication and follow your doctor's instructions for best results.

Women can experience hair loss due to various factors, including genetics, hormonal changes (such as menopause, PCOS, birth control changes, and postpartum), medical conditions (like thyroid disorders and autoimmune diseases), nutritional deficiencies, stress, damaging hairstyling practices, certain medications, aging, and trauma. The most common forms of hair loss in women are Androgenetic Alopecia (a genetic condition causing thinning hair and pattern baldness) and Telogen Effluvium (temporary hair shedding due to stress, illness, surgery, shock to the system, or other transient factors, which can sometimes become chronic or even unmask underlying Androgenetic Alopecia). The specific cause varies and often requires evaluation by a healthcare professional to determine the underlying reason and appropriate treatment options.

The good news is that we're here to help. At Tangl, we're committed to developing the most advanced, thoroughly vetted, and carefully curated treatments to provide a personalized solution for your unique hair journey.

Some side effects include:

• Headache
• Local scalp irritation, including redness or minor swelling
• Insomnia, nausea, dry mouth
• Hair shedding: It's common to experience increased hair shedding initially. This is typically a temporary phase as hair follicles regenerate.
• Some may also experience changes in hair texture and color.

These are not all the possible side effects of Spiroxidil™. For more information, read the Drug Safety Information. Be sure to ask your healthcare provider about seeking treatment with Spiroxidil™.

It is important to stop therapy and contact your physician in any case of serious side effects.

Minoxidil, one of the active ingredients in Spiroxidil™ is highly toxic to animals. Cats are particularly sensitive to this medication; even trace amounts can be life-threatening. Always store Spiroxidil™ in a secure location out of reach of pets.

Please read the full Drug Safety Information for Spiroxidil™ for more on safety and best practices for use around pets.