• The most powerful prescription nail fungus formula on the market 
• Combines 5 anti-fungals, anti-inflammatories and fungal-wall disruptors to eliminate fungus at the root 
• Provides visible results
• Starts working to restore the appearance and health of your nails
• Nourishes and strengthens nails, promoting healthier growth and preventing future infection

Itraconazole (1%)  is an antifungal medication commonly used to treat nail fungus infections, a condition known as onychomycosis. It belongs to a class of drugs called triazole antifungals. Itraconazole works by inhibiting the synthesis of ergosterol, a crucial component of fungal cells. By inhibiting squalene epoxidase, terbinafine disrupts the synthesis of ergosterol. Without sufficient ergosterol, fungal cell membranes become structurally unstable and more permeable. Additionally, the accumulation of toxic squalene and other intermediates within the fungal cells further disrupts the integrity and function of the cell membrane. 

Fluconazole (5%)  interferes with the activity of certain enzymes known as cytochrome P450 enzymes that are involved in the synthesis of ergosterol, a key component of fungal cell membranes. These enzymes are part of the ergosterol biosynthesis pathway, similar to the way they are targeted by other azole antifungal medications. 

Terbinafine (5%) targets an enzyme called squalene epoxidase, which is a key enzyme in the fungal ergosterol biosynthesis pathway. Ergosterol is a vital component of fungal cell membranes, similar to cholesterol in human cell membranes.

Ibuprofen (2%) acts on isolated dermatophytes may related to the inhibitory action of on-secreted COX that is produced by fungal cells and not to direct toxicity that NSAIDs may have. Inhibition of prostaglandin production is not the only mechanism of ibuprofen in fungal cells.

Tea tree oil (10%) contains compounds called terpenes, with terpinen-4-ol being the most well-known and active component. Terpinen-4-ol is believed to have antifungal activity by disrupting the structure and function of fungal cell membranes. It may interfere with fungal enzymes and proteins, leading to the inhibition of fungal growth and proliferation.

Apply 1-2 drops of solution to each affected toenail once daily.

Wait for at least 10 minutes after showering, bathing, or washing before applying.

Tangl NAIL is for use on toenails and surrounding skin only.

Do not use over nail polish or paint. Do not use in your mouth, eyes, or fingernails.

Prescription topical antifungal medications for onychomycosis are recommended for those with mild to moderate nail fungal infections, particularly in the early stages, limited to a few nails, or when patients prefer topical treatment or have medical reasons for avoiding oral antifungals

Fungal toenails, or onychomycosis, are primarily caused by dermatophytes and thrive in warm, moist environments like toenails within closed shoes. Factors such as nail trauma, poor hygiene, aging, weakened immune systems, and genetic predisposition can contribute to fungal nail infections. Additionally, communal areas like public pools and nail salons can facilitate the spread of these infections. Prevention involves maintaining foot hygiene, proper nail care, well-ventilated footwear, and avoiding barefoot exposure in public places. 

Tangl NAIL is a compounded medication, which means it's a custom blend of multiple active ingredients formulated to target specific health concerns. In this case, Tangl NAIL is designed to tackle nail fungus infections (onychomycosis) through a multi-faceted approach.

The formula includes Itraconazole, a triazole antifungal that inhibits ergosterol synthesis in fungal cells, disrupting their structure and function. Terbinafine, another key ingredient, targets the same pathway by inhibiting squalene epoxidase, leading to membrane instability. Fluconazole works by interfering with cytochrome P450 enzymes involved in ergosterol synthesis, further hindering fungal growth. Additionally, Ibuprofen's action on dermatophytes is linked to non-secreted COX produced by fungal cells, with prostaglandin inhibition being one of the mechanisms. Tea tree oil, primarily terpinen-4-ol, disrupts fungal cell membranes, potentially interfering with enzymes and proteins to inhibit fungal growth.

The synergistic effect of Tangl NAIL's compounded ingredients effectively kills fungal spores, inhibits further growth, and promotes nail matrix regeneration for healthier nails.

Nail fungus is a stubborn condition that commonly takes several months to treat. Tangl NAIL may take several months to be effective, as the medication has to penetrate the nail and reach the site of the infection. Improvement is typically gradual, with the nail growing out over time. Best results are seen around the 9-12 month mark with daily use. It’s important to continue to with the treatment to achieve full results. 

Always consult your Tangl dermatologist for personalized advice.

No, you should not use topical Tangl NAIL if you are pregnant, breastfeeding, or planning to become pregnant.

These are not all the possible side effects of Tangl NAIL. For more information, read the Drug Safety Information. Be sure to ask your healthcare provider about seeking treatment with Tangl NAIL.

It is important to stop therapy and seek medical attention in any case of serious side effects.